Gold P E, Delanoy R L, Merrin J
Brain Res. 1984 Jul 2;305(1):103-7. doi: 10.1016/0006-8993(84)91124-7.
Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development of LTP in a dose-related manner comparable to that seen previously in behavioral studies. Such results suggest that the development of this long-lasting electrophysiological change can be regulated by peripheral catecholamine levels in a manner analogous to that seen in behavioral studies of memory.
长期增强效应（LTP）作为一种用于研究记忆生物学的神经生理模型，已受到广泛关注。本实验研究了齿状回中LTP对外周注射苯丙胺和肾上腺素修饰的敏感性。两种药物均以与先前行为学研究中所见相似的剂量相关方式增强了LTP的发展。这些结果表明，这种持久的电生理变化的发展可以通过外周儿茶酚胺水平以类似于记忆行为学研究中所见的方式进行调节。
