D-葡萄糖异头物对大鼠胃酸分泌增强的不同影响。

Different effects of D-glucose anomers on enhanced secretion of gastric acid in rat.

作者信息

Sakaguchi T, Ishiguro K, Saitoh R, Hasegawa A, Sakuma Y

出版信息

Brain Res. 1984 Jul 2;305(1):144-7. doi: 10.1016/0006-8993(84)91129-6.

Abstract

The injection of alpha-, beta-, or equilibrated (alpha: 36%, beta: 64%) D-glucose solution into the cranial side of the carotid artery decreased gastric acid output caused by insulin in rats with bilateral adrenalectomy. This effect was not reproduced after vagotomy at the cervical level. Of the 3 forms of D-glucose solution the effect of beta-D-glucose was greatest. The injection of isotonic NaCl solution, however, produced no change in acid output. These results suggest that blood beta-D-glucose may play a predominant role in activating a brain mechanism which controls gastric acid secretion via the vagus nerve.

摘要

向双侧肾上腺切除的大鼠颈动脉颅侧注射α-、β-或平衡型（α：36%，β：64%）D-葡萄糖溶液，可降低胰岛素引起的胃酸分泌。在颈部切断迷走神经后，这种效应未再现。在3种形式的D-葡萄糖溶液中，β-D-葡萄糖的作用最大。然而，注射等渗NaCl溶液对胃酸分泌没有影响。这些结果表明，血液中的β-D-葡萄糖可能在激活一种通过迷走神经控制胃酸分泌的脑机制中起主要作用。