Sakaguchi T, Ishiguro K, Hayashi Y, Hasegawa A
Exp Neurol. 1984 Apr;84(1):231-6. doi: 10.1016/0014-4886(84)90019-0.
Acid outputs from the stomach were measured after venous administration of D-glucose and its optical anomers in men with insulin hypoglycemia. A significant decrease in gastric acid output was noted after the administration of 277 mM alpha-D-glucose, 277 mM optically equilibrated D-glucose consisting of 36% alpha-anomer and 64% beta-anomer, or 277 mM beta-D-glucose. The effect of beta-D-glucose was most potent in the three forms of D-glucose. NaCl solution, however, produced no appreciable change in the acid outputs. Our findings suggested that, in humans, beta-D-glucose in the blood may play an important role in the activation of glucose-sensitive mechanisms controlling vagally mediated secretion of gastric acid.
在患有胰岛素低血糖症的男性中，静脉注射D-葡萄糖及其旋光异构体后，测量了胃酸分泌量。静脉注射277 mM的α-D-葡萄糖、由36%的α-异构体和64%的β-异构体组成的277 mM旋光平衡D-葡萄糖或277 mM的β-D-葡萄糖后，胃酸分泌量显著下降。在三种D-葡萄糖形式中，β-D-葡萄糖的作用最为显著。然而，NaCl溶液对胃酸分泌量没有产生明显变化。我们的研究结果表明，在人类中，血液中的β-D-葡萄糖可能在激活控制迷走神经介导的胃酸分泌的葡萄糖敏感机制中发挥重要作用。
