D-葡萄糖异头物对人体甜度、味觉及胃酸分泌的影响。

Effects of D-glucose anomers on sweetness, taste and gastric acid secretion in man.

作者信息

Sakaguchi T, Hatta H, Niijima A, Kondoh Y, Yamazaki M

出版信息

J Auton Nerv Syst. 1984 Dec;11(4):367-72. doi: 10.1016/0165-1838(84)90084-5.

Abstract

Gastric acid outputs were examined in human subjects after lingual applications of d-glucose and its anomers. A dose-dependent increase in the acid output was noted following the application of equilibrated D-glucose consisting of 36% alpha- and 64% beta-anomer. The response was not reproduced after administration of atropin. The magnitude of acid output produced by alpha-anomer was different from that induced by beta-anomer in men who could not differentiate between sweetness of the two anomers. Results indicate that recognition of sweetness in the cortex is unrelated to the gastric response, and suggest that a subcortical mechanism may detect qualitative differences in taste and produce the oral phase of gastric acid secretion via vagus action in humans.

摘要

在人体受试者中，研究了经舌部应用d-葡萄糖及其异头物后胃酸的分泌情况。应用由36%的α-异头物和64%的β-异头物组成的平衡型D-葡萄糖后，观察到胃酸分泌呈剂量依赖性增加。给予阿托品后未再现该反应。在无法区分两种异头物甜度的男性中，α-异头物产生的胃酸分泌量与β-异头物引起的不同。结果表明，皮质对甜味的识别与胃反应无关，并提示皮层下机制可能检测味觉的质的差异，并通过迷走神经作用产生人类胃酸分泌的口腔期。