Brawn P N
Cancer. 1984 Aug 15;54(4):620-3. doi: 10.1002/1097-0142(1984)54:4<620::aid-cncr2820540405>3.0.co;2-a.
Ten patients with noninvasive papillary lesions who subsequently developed invasive bladder carcinoma were identified. Five of the 10 patients developed an invasive carcinoma in a location distinctly separate from any preceding papillary lesion. The remaining five patients developed an invasive carcinoma in the same general location as a preceding papillary lesion. These findings suggest that invasive bladder carcinomas, which develop in a patient with previous noninvasive papillary lesions, often arise from nonpapillary urothelium adjacent the noninvasive papillary lesion rather than directly from the preceding papillary lesion.
