Isa S S, Almaraz R, Magovern J
Cancer. 1984 Sep 1;54(5):939-42. doi: 10.1002/1097-0142(19840901)54:5<939::aid-cncr2820540533>3.0.co;2-y.
The twenty-third case of penile leiomyosarcoma in the literature is reported, and all cases are reviewed. Clinically and pathologically these tumors fall into two groups, superficial and deep. Superficial tumors grow slowly, and tend to recur locally, but have a high salvage rate and good prognosis. The recommended treatment is local excision with negative margins. Recurrences are usually amenable either to re-excision or amputation with some degree of success. Deep tumors exhibit a more aggressive behavior, and have a poorer prognosis. Despite radical surgery the salvage rate is low, and most patients die from disseminated disease one or two years after diagnosis. Metastases to inguinal lymph nodes are uncommon, and should be treated aggressively in the absence of distant metastases. The role of adjuvant radiotherapy and chemotherapy in treating deep tumors should be investigated.
本文报告了文献中第23例阴茎平滑肌肉瘤病例，并对所有病例进行了回顾。从临床和病理角度来看，这些肿瘤可分为两组，即浅表型和深部型。浅表型肿瘤生长缓慢，易于局部复发，但挽救率高，预后良好。推荐的治疗方法是切缘阴性的局部切除术。复发通常可通过再次切除或截肢获得一定程度的成功。深部型肿瘤表现出更具侵袭性的行为，预后较差。尽管进行了根治性手术，挽救率仍较低，大多数患者在诊断后一两年内死于播散性疾病。腹股沟淋巴结转移并不常见，在无远处转移的情况下应积极治疗。应研究辅助放疗和化疗在治疗深部型肿瘤中的作用。
