Khayat A, Dencker L
Chem Biol Interact. 1984 Jul;50(2):123-33. doi: 10.1016/0009-2797(84)90089-9.
Selenium is known to form complexes with heavy metals in the blood and thus increase the retention time of the metals in several organs, especially in the reticulo-endothelial system. Selenium may similarly cause retention of mercury in the lung after metallic mercury (Hg0) inhalation. This study, comparing the effects of tellurium with those of selenium (both in group '6b' of the periodical system), showed that Te(IV) was as effective as Se(IV) and Se(VI) (all given in a dose of 10 mumol/kg body wt.) in retaining inhaled 203Hg0 (1.5 mumol/kg body wt.) in the lung (presumably 203Hg2+ after oxidation). Te(VI) had to be given in a dose of 100 mumol/kg body wt to produce the same effect. As in the lung, also in other organs tellurium caused a dose-dependent increase in mercury retention. At a dose level of 10 mumol Te(IV) per kg body wt. the mercury retention ratios (treated/control) were 140 for the lung and 8.6 for the whole body. The corresponding figures for Te(VI) (10, 30 and 100 mumol/kg body wt.) were 10, 73 and 120 and 3.7, 3.9 and 4.3, respectively. Retention of i.v. injected 203HgCl2 was increased by pre-administration of tellurium, again in a dose-dependent manner and Te(IV) being 3-10 times more effective than Te(VI). The kidney and the spleen were the dominant organs, as is the case after Se pretreatment. Anions of other elements, arsenite, arsenate, chromate, molybdate and wolframate (30 mumol/kg body wt.), did not affect the retention of 203Hg in lung or any other organ, or in the whole body after inhalation of 203Hg0. It is suggested that Te(IV) may easily be reduced to Te2- (in analogy with selenium) which may complex with Hg2+. The liability for Te(VI) to be reduced to Te2- appears to be approx. 10 times lower.
已知硒能在血液中与重金属形成络合物，从而延长金属在多个器官中的滞留时间，尤其是在网状内皮系统中。吸入金属汞（Hg0）后，硒可能同样会导致汞在肺部滞留。本研究比较了碲与硒（二者均在元素周期表的‘6b’族）的作用，结果表明，在使吸入的203Hg0（1.5 μmol/kg体重）滞留在肺部（氧化后可能为203Hg2+）方面，Te(IV)与Se(IV)和Se(VI)的效果相同（均以10 μmol/kg体重的剂量给药）。Te(VI)必须以100 μmol/kg体重的剂量给药才能产生相同效果。与在肺部的情况一样，在其他器官中碲也会导致汞滞留量呈剂量依赖性增加。在每千克体重给予10 μmol Te(IV)的剂量水平下，肺部的汞滞留率（处理组/对照组）为140，全身为8.6。Te(VI)（10、30和100 μmol/kg体重）的相应数字分别为10、73和120以及3.7、3.9和4.3。预先给予碲会使静脉注射的203HgCl2的滞留量增加，同样呈剂量依赖性，且Te(IV)的效果比Te(VI)强3至10倍。肾脏和脾脏是主要器官，硒预处理后也是这种情况。其他元素的阴离子，亚砷酸盐、砷酸盐、铬酸盐、钼酸盐和钨酸盐（30 μmol/kg体重），在吸入203Hg0后，不会影响203Hg在肺部或任何其他器官或全身的滞留。有人认为，Te(IV)可能很容易被还原为Te2-（类似于硒），后者可能与Hg2+形成络合物。Te(VI)被还原为Te2-的倾向似乎约低10倍。
