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低剂量汞蒸汽暴露后硒对小鼠体内汞分布的影响。

The influence of selenium on mercury distribution in mice after exposure to low dose Hg0 vapours.

作者信息

Hansen J C, Kristensen P, Westergaard I

出版信息

J Appl Toxicol. 1981 Jun;1(3):149-53. doi: 10.1002/jat.2550010304.

Abstract

The influence of selenium administration on retention, elimination and organ distribution of mercury was studied in female mice exposed to 30 or 80 micrograms m -3 mercury vapour. The results demonstrated that, as after low doses of mercuric mercury, only excess selenium reduced the elimination of retained mercury vapour from the whole body. However, selenium was able to influence the organ distribution of mercury, even when the whole body burden of mercury was not affected. In mice, contrary to rats, selenium increased the lung and kidney concentrations of mercury without affecting its concentration in the liver.

摘要

在暴露于30或80微克/立方米汞蒸气的雌性小鼠中,研究了给予硒对汞的潴留、消除及器官分布的影响。结果表明,如同低剂量汞暴露后一样,只有过量的硒会减少全身潴留汞蒸气的消除。然而,即使汞的全身负荷未受影响,硒也能够影响汞的器官分布。与大鼠相反,在小鼠中,硒增加了肺和肾中的汞浓度,而不影响其在肝脏中的浓度。

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