置信度估计与临床试验规模

Confidence estimation and the size of a clinical trial.

作者信息

McHugh R B, Le C T

出版信息

Control Clin Trials. 1984 Jun;5(2):157-63. doi: 10.1016/0197-2456(84)90121-1.

Abstract

The general procedure for sample size determination based upon the confidence interval approach is reviewed and presented for both absolute and relative precision stipulations. The relationship between precision and sample size is discussed and methods for sample size determination for clinical trials are presented and illustrated with numerical examples.

摘要

回顾并介绍了基于置信区间方法确定样本量的一般程序，包括绝对精度规定和相对精度规定。讨论了精度与样本量之间的关系，并给出了临床试验样本量确定的方法，并用数值例子加以说明。