Wang S R, Yang C M, Wang S M
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1984 Feb;17(1):48-54.
Sputum from asthmatics contained a mediator similar to slow reacting substance of anaphylaxis (SRS-A), capable of inducing contraction of guinea pig ileum. This mediator possessed the major characteristics of SRS-A, including stability in both neutral and alkaline solutions, lability in boiling acidic solution, destruction by arylsulfatase, inhibition by FPL 55712 and resistance to diphenhy dramine . Thus, we proved that the "SRS-A like" mediator was in fact SRS-A. The activity of histamine in these patients' sputa could be inhibited only by diphenhydramine, but could not be altered by any of the other treatments noted above.
哮喘患者痰液中含有一种类似于过敏反应慢反应物质（SRS-A）的介质，能够引起豚鼠回肠收缩。这种介质具有SRS-A的主要特性，包括在中性和碱性溶液中稳定，在沸腾酸性溶液中不稳定，被芳基硫酸酯酶破坏，被FPL 55712抑制以及对苯海拉明有抗性。因此，我们证明了“类SRS-A”介质实际上就是SRS-A。这些患者痰液中组胺的活性仅能被苯海拉明抑制，但不能被上述任何其他处理改变。
