Engstrom F L, Chow S Y, Kemp J W, Woodbury D M
Epilepsia. 1984 Aug;25(4):518-25. doi: 10.1111/j.1528-1157.1984.tb03454.x.
DBA/2J (DBA) mice are susceptible to audiogenic seizures (ASs) in an age-dependent manner. Anion transport as measured by radioiodide uptake was determined in thyroid gland, salivary gland, skeletal muscle, cerebral cortex, cerebellum, brainstem, and CSF from these mice at various ages. Anion transport was also determined in C57BL/6J(C57) mice, an AS-resistant strain. In thyroid, DBA mice had an enhanced ability to concentrate iodide at 21 days of age when they have maximal AS susceptibility, as compared with the same-aged C57 mice. This difference in thyroid function was less marked at 40 days of age, when DBA mice are less AS susceptible, and was absent at 110 days of age, when DBA mice are AS resistant. In brain, differences in iodide uptake were also noted between these two strains of mice at 21 days of age. DBA mice had an increased concentration of iodide in CSF, an indication that they have a defect in the transport of iodide out of the CSF across the choroid plexus. In addition, DBA mice had a lower ratio of cerebral cortex to CSF iodide, which suggests that DBA mice have a defect in the transport of this anion into cerebral cortical cells from brain interstitial fluid. These differences in iodide transport in brain decreased with age as the AS susceptibility of DBA mice decreased. These results suggest a relation between anion transport in thyroid gland, cerebral cortex, and choroid plexus and AS susceptibility in DBA mice at 21 days of age.
DBA/2J（DBA）小鼠对听源性癫痫发作（ASs）具有年龄依赖性易感性。通过放射性碘摄取测量的阴离子转运在这些不同年龄小鼠的甲状腺、唾液腺、骨骼肌、大脑皮层、小脑、脑干和脑脊液中进行了测定。在AS抗性品系C57BL/6J（C57）小鼠中也测定了阴离子转运。在甲状腺中，与同龄C57小鼠相比，21日龄时DBA小鼠在AS易感性最高时具有增强的碘浓缩能力。在40日龄时，DBA小鼠对AS的易感性较低，这种甲状腺功能差异不太明显；在110日龄时，DBA小鼠对AS具有抗性，这种差异不存在。在大脑中，这两种品系小鼠在21日龄时碘摄取也存在差异。DBA小鼠脑脊液中碘浓度升高，这表明它们在碘从脑脊液穿过脉络丛转运出方面存在缺陷。此外，DBA小鼠大脑皮层与脑脊液碘的比率较低，这表明DBA小鼠在将这种阴离子从脑间质液转运到大脑皮层细胞方面存在缺陷。随着DBA小鼠AS易感性降低，大脑中碘转运的这些差异随年龄减小。这些结果表明，21日龄时DBA小鼠甲状腺、大脑皮层和脉络丛中的阴离子转运与AS易感性之间存在关联。
