家族性白蛋白异常血症性甲状腺素血症（FDH）：检测游离T4水平的“类似物”方法的不足之处。
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels.
作者信息
De Nayer P, Malvaux P, Beckers C
出版信息
Eur J Nucl Med. 1984;9(6):284-5. doi: 10.1007/BF00803252.
Free-T4 levels were determined in familial dysalbuminemic hyperthyroxinemia (FDH) subjects. In agreement with their euthyroid status free-T4 levels were within the normal range when tested by equilibrium dialysis and by the FT4 Immophase method (Corning Medical). However, when using the recently introduced "analog" methods, either Amerlex FT4 or Becton-Dickinson FT4, Free-T4 values were markedly higher than the control values. This discrepancy is probably due to artifactual binding of the labeled analog to the fraction of albumin exhibiting an excessive affinity for T4.
对家族性异常白蛋白血症性甲状腺素血症（FDH）患者测定了游离T4水平。与他们的甲状腺功能正常状态一致，通过平衡透析法和FT4免疫比浊法（康宁医疗公司）检测时，游离T4水平在正常范围内。然而，当使用最近推出的“类似物”方法，即Amerlex FT4或贝克曼库尔特FT4时，游离T4值明显高于对照值。这种差异可能是由于标记类似物与对T4具有过高亲和力的白蛋白部分发生了人为结合。
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