Nitta K, Takayanagi G, Terasaki Y, Kawauchi H
Experientia. 1984 Jul 15;40(7):712-3. doi: 10.1007/BF01949737.
Among skin extracts of various frogs, lectin activity was found only in fractions prepared from Xenopus laevis skin. 3 skin lectins have been separated. Among these, the lectin designated S2-Dlc was isolated in a homogeneous state and showed a preferential agglutination of Ehrlich and S-180 ascites tumor cells; other tumor cells and human erythrocytes were not agglutinated. The lectin-dependent agglutination was inhibited by D-fucose, L-arabinose, D-galactose, lactose and lactulose. The sugar specificity of this lectin is similar to that of the lectin from Xenopus laevis eggs which agglutinates Ehrlich and S-180 ascites cells.
在各种青蛙的皮肤提取物中，仅在非洲爪蟾皮肤制备的组分中发现凝集素活性。已分离出3种皮肤凝集素。其中，命名为S2-Dlc的凝集素以均一状态分离出来，对艾氏腹水瘤细胞和S-180腹水瘤细胞表现出优先凝集作用；其他肿瘤细胞和人红细胞未被凝集。D-岩藻糖、L-阿拉伯糖、D-半乳糖、乳糖和乳果糖可抑制凝集素依赖性凝集。这种凝集素的糖特异性与来自非洲爪蟾卵的凝集素相似，后者可凝集艾氏腹水细胞和S-180腹水细胞。
