Varskeviciené Z Z, Cerniauskiené R C, Grybauskas P S
Gen Physiol Biophys. 1984 Feb;3(1):47-53.
Alpha-tocopherol content and production of malondialdehyde (MDA) was measured in liver, kidney, heart, lung, brain and skeletal muscle homogenates of control and hypoxic rats (following a 2-h-exposure to 200 mm Hg): the samples were incubated at 37 degrees C in air for 1 h. MDA production showed no relation with the content of alpha-tocopherol in control and hypoxic rats. In control animals, the lowest MDA level was found in lungs: it was several fold lower than in other tissues. After hypobaric exposure, a marked increase in MDA level could be observed in lungs only. No marked changes in alpha-tocopherol concentration could be observed in any of the tissues tested. A single i.p. injection of 25 and 50 mg/alpha-tocopherol acetate/kg body mass, 2 hours prior to the exposure produced organ-specific accumulation of alpha-tocopherol. Both doses of alpha-tocopherol resulted in a reduced (by about 40%) production of MDA in lung homogenates. The addition of alpha-tocopherol (750 nmol/g wet tissue mass) to homogenates from control and hypoxic rats prior to the incubation resulted in a marked inhibition of MDA production in all tissues (49-70%).
在对照大鼠和缺氧大鼠（暴露于200 mmHg 2小时后）的肝脏、肾脏、心脏、肺、脑和骨骼肌匀浆中测量了α-生育酚含量和丙二醛（MDA）的生成：样品在37℃空气中孵育1小时。在对照大鼠和缺氧大鼠中，MDA的生成与α-生育酚含量无关。在对照动物中，肺中的MDA水平最低：比其他组织低几倍。低压暴露后，仅在肺中观察到MDA水平显著升高。在所测试的任何组织中均未观察到α-生育酚浓度有明显变化。在暴露前2小时，单次腹腔注射25和50 mg/α-生育酚醋酸酯/千克体重可使α-生育酚在器官中特异性蓄积。两种剂量的α-生育酚均导致肺匀浆中MDA生成减少（约40%）。在孵育前向对照大鼠和缺氧大鼠的匀浆中添加α-生育酚（750 nmol/g湿组织质量）可显著抑制所有组织中MDA的生成（49 - 70%）。
