Horner K C
Inserm U229, Laboratoire d'Audiologie Expérimentale, Hôpital Pellegrin, Bordeaux, France.
Hear Res. 1993 Jun;68(1):1-18. doi: 10.1016/0378-5955(93)90059-a.
A guinea pig model with surgically induced endolymphatic hydrops of the inner ear has been developed and studied over the past thirty years. The aim of such studies is to obtain insight into physiological processes associated with endolymphatic hydrops in man and in particular in Menière's disease where endolymphatic hydrops is systematically encountered at post-mortem examination of the temporal bones. The present review attempts to draw together the data pertaining to functional modifications of inner ear function in the animal model. For simplicity the data are categorised under five main titles: electrochemical modifications, electrophysiological modifications, pressure and hydrops, sensitivity to other insults and vestibular dysfunction. One of the most striking observations that can be made is that the data originating from different authors are very variable. There is, however, some evidence suggesting that the evolution of the auditory dysfunction could be considered as consisting of a series of different phases. This kind of information could serve as a basic framework for future research on the animal model.
在过去三十年中，已经建立并研究了一种通过手术诱导内耳内淋巴积水的豚鼠模型。此类研究的目的是深入了解与人类内淋巴积水相关的生理过程，尤其是在梅尼埃病中，在颞骨的尸检中经常会系统性地发现内淋巴积水。本综述试图汇总与该动物模型中内耳功能的功能改变相关的数据。为简单起见，数据分为五个主要标题：电化学改变、电生理改变、压力与积水、对其他损伤的敏感性以及前庭功能障碍。可以得出的最显著观察结果之一是，来自不同作者的数据差异很大。然而，有一些证据表明，听觉功能障碍的演变可以被认为是由一系列不同阶段组成的。这类信息可以作为未来对该动物模型研究的基本框架。
