Habs M, Jahn S A, Schmähl D
J Cancer Res Clin Oncol. 1984;108(1):154-6. doi: 10.1007/BF00390988.
In the Sahelian countries coloquint seed tar is used in traditional medicine. A condensate from the seed of Citrullus colocynthis was obtained in a camel nomad settlement. It contained a large number of polycyclic aromatic hydrocarbons, including known carcinogens [e.g., benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene, benzo(j)fluoranthene]. The dose-related carcinogenic activity of this condensate was established after chronic epicutaneous application to mouse skin. We conclude that the manufacture and use of coloquint tar and related compounds may involve a health hazard and could lead to the development of cancer.
在萨赫勒地区国家，药西瓜籽焦油被用于传统医学。在一个骆驼游牧民定居点获得了药西瓜（Citrullus colocynthis）种子的冷凝物。它含有大量多环芳烃，包括已知的致癌物[例如苯并(a)芘、苯并(a)蒽、苯并(b)荧蒽、苯并(j)荧蒽]。在对小鼠皮肤进行慢性经皮应用后，确定了这种冷凝物与剂量相关的致癌活性。我们得出结论，药西瓜焦油及相关化合物的制造和使用可能涉及健康危害，并可能导致癌症的发生。
