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听神经瘤的流行病学

Epidemiology of acoustic neuromas.

作者信息

Tos M, Thomsen J

出版信息

J Laryngol Otol. 1984 Jul;98(7):685-92. doi: 10.1017/s0022215100147292.

Abstract

In Denmark one surgical team, during the last 7 years, has performed about 80 per cent of all acoustic neuroma surgery. Because of this centralization, in such a limited population as that of Denmark, we have attempted to make a epidemiological survey of all diagnosed tumours in the period from 1976 to 1983. Systematic and prospective records were made by the authors of all patients with translabyrinthine operations, and data on patients with suboccipital operations were collected retrospectively from the six neurosurgical departments in Denmark. The average annual incidence was 8 tumours per million inhabitants, with the highest incidence of approximately 13 tumours per million occurring in Copenhagen County. The incidence reported in previously published autopsy series is 800-900 times higher and the following may serve as an explanation for this enormous difference: Autopsy series are in all probability based on highly selected cases; they are predominantly based on elderly people and the incidence is not directly applicable to the population at large. Several of the silent tumours from the autopsy series were located in the cochlea or in the labyrinth and not in the internal ear canal. The conclusion from our study is that both the knowledge and data available at present are insufficient to serve as a basis for an actual calculation of incidence and prevalence of acoustic neuromas.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在丹麦,一个外科团队在过去7年里完成了约80%的所有听神经瘤手术。由于这种集中化,在丹麦这样人口有限的国家,我们试图对1976年至1983年期间所有确诊的肿瘤进行一项流行病学调查。作者对所有接受经迷路手术的患者进行了系统且前瞻性的记录,并从丹麦的六个神经外科部门回顾性收集了接受枕下手术患者的数据。年平均发病率为每百万居民8例肿瘤,哥本哈根县的发病率最高,约为每百万13例。先前发表的尸检系列报告的发病率要高出800 - 900倍,以下内容或许可以解释这种巨大差异:尸检系列很可能基于高度选择性的病例;它们主要基于老年人,且该发病率不能直接适用于广大人群。尸检系列中的一些无症状肿瘤位于耳蜗或迷路,而非内耳道。我们研究的结论是,目前现有的知识和数据不足以作为实际计算听神经瘤发病率和患病率的基础。(摘要截选至250词)

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