Armstrong D M, Drew T
J Physiol. 1984 May;350:33-54. doi: 10.1113/jphysiol.1984.sp015187.
Microwires chronically implanted in the pericruciate cortex of free-to-move cats were used to record extracellularly from cortical neurones and to deliver intracortical stimulation. Natural stimulation of cutaneous and/or deep mechanoreceptors in limbs and trunk evoked discharges in 89% of 165 neurones, 57% of which were pyramidal tract neurones. Out of 112 cells with receptive fields on the contralateral forelimb, 41% had cutaneous fields, 29% had fields involving deep tissues and 30% were driven from both sources. Cutaneous receptive fields were much commoner than deep ones among cells with fields including the forefoot; this relationship was reversed for cells with more proximal fields. Many more cells had distal than proximal fields. The 'zones' of the forelimb (i.e. foot, wrist, elbow, shoulder) provided input to widespread and overlapping cell populations within the coronal gyrus and the lateral parts of the anterior and posterior sigmoid gyri. Despite the overlap a somatotopy existed with successively more distal limb zones represented successively further laterally in the pericruciate area. Intracortical stimulation (eleven cathodal pulses, duration 0.2 ms, frequency 330 Hz, intensity 35 microA or less) evoked flick movements of the contralateral limbs which were abolished by pyramidectomy. In the forelimb, shoulder movements were commonest and elbow, wrist and digits were represented with decreasing frequency. Both for 35 microA and for threshold stimulation the distributions of the effective electrodes revealed an overlapping somatotopy such that the wrist movements were almost restricted to the coronal gyrus and shoulder movements were most often evoked from the lateral part of the anterior sigmoid gyrus. The movement and receptive field somatotopies overlapped heavily but the former showed a distinct lateral shift relative to the latter. As a result shoulder movements were not uncommonly evoked from the coronal gyrus although the shoulder provided almost no input to cells in that area.
将微丝长期植入可自由活动猫的十字周皮层，用于细胞外记录皮层神经元活动并进行皮层内刺激。对四肢和躯干的皮肤和/或深部机械感受器进行自然刺激，在165个神经元中有89%引发了放电，其中57%是锥体束神经元。在112个对侧前肢有感受野的细胞中，41%有皮肤感受野，29%有涉及深部组织的感受野，30%由两种来源驱动。在前足包括在内的感受野细胞中，皮肤感受野比深部感受野更为常见；对于近端感受野的细胞，这种关系则相反。具有远端感受野的细胞比近端感受野的细胞多得多。前肢的“区域”（即足、腕、肘、肩）为冠状回以及前、后乙状回外侧部分内广泛且重叠的细胞群提供输入。尽管存在重叠，但仍存在躯体定位，肢体区域越靠远端，在十字周区域中越靠外侧依次代表。皮层内刺激（11个阴极脉冲，持续时间0.2毫秒，频率330赫兹，强度35微安或更低）引发对侧肢体的轻弹运动，这种运动在切除锥体后消失。在前肢中，肩部运动最常见，肘、腕和手指的运动出现频率逐渐降低。对于35微安和阈值刺激，有效电极的分布都显示出重叠的躯体定位，使得腕部运动几乎局限于冠状回，而肩部运动最常从前乙状回外侧部分引发。运动和感受野的躯体定位严重重叠，但前者相对于后者有明显的侧向偏移。结果，尽管肩部几乎没有为该区域的细胞提供输入，但冠状回仍不罕见地引发肩部运动。
