深部脑刺激抑制疼痛的相关解剖学与临床研究

A correlative anatomical and clinical study of pain suppression by deep brain stimulation.

作者信息

Boivie Jörgen, Meyerson Björn A

机构信息

Department of Anatomy, Karolinska Institutet, Stockholm, Sweden Department of Neurology, University Hospital, Uppsala, Sweden Department of Neurosurgery, Karolinska Sjukhuset, S-10401, Stockholm Sweden.

出版信息

Pain. 1982 Jun;13(2):113-126. doi: 10.1016/0304-3959(82)90022-7.

DOI:10.1016/0304-3959(82)90022-7

PMID:6750509

Abstract

The clinical results of electrical stimulation in medial thalamic regions for cancer pain have been correlated with the exact location of the stimulation sites. Five brains were examined by post-mortem histology. Chronic implantation of enamel coated platinum-iridium electrodes for up to 17 months caused relatively mild glial and neuronal reactions and no significant haemorrhage or infarction. The anatomical verifications showed that the electrodes were close to, but not exactly in, the regions defined by the stereotactic coordinates. From the clinico-anatomical correlations it appears that good pain relief can be obtained by electrical stimulation in the periventricular gray region of the posterior thalamus.

摘要

丘脑内侧区域电刺激治疗癌痛的临床结果与刺激部位的确切位置相关。对5个大脑进行了尸检组织学检查。长期植入涂有珐琅的铂铱电极长达17个月，引起相对轻微的胶质细胞和神经元反应，无明显出血或梗死。解剖学验证表明，电极靠近但并不完全位于立体定向坐标所定义的区域。从临床与解剖学的相关性来看，丘脑后部室周灰质区域的电刺激似乎可以有效缓解疼痛。