Bhagavan B S, Ruffier J, Shinn B
Hum Pathol. 1982 Oct;13(10):898-904. doi: 10.1016/s0046-8177(82)80049-x.
Splendore-Hoeppli phenomenon, the in vivo formation of eosinophilic radiate structures around microorganisms and biologically inert substances, may simulate actinomycotic sulfur granules and has been recognized in extragenital sites. In the lower female genital tract, the authors have noted these pseudoactinomycotic radiate granules (PAMRAGs) in both the presence and the absence of intrauterine contraceptive devices. To elucidate the nature and morphogenesis of PAMRAGs, the light microscopic morphologic features of PAMRAGs were studied by means of a battery of special stains. The absence of central branching filaments or diptheroid forms in PAMRAGs serves to distinguish them from true actinomycotic sulfur granules. Using the immunoperoxidase technique, the authors examined PAMRAGs for the presence of immunoglobulin, complement, and fibrin. Their studies showed that PAMRAGs contain neutral glycoproteins, lipid, and calcium with no demonstrable microorganisms, immunoglobulin, complement, or fibrin. The authors do not support the assertions of others that Splendore-Hoeppli radiate bodies are immune complexes derived from host serum proteins. They speculate that PAMRAGs of the genital tract are derived from host leukocytes that aggregate in response to the commonly present bacteria, parasites, or inert foreign bodies that initiate the Splendore-Hoeppli phenomenon and the morphogenesis of PAMRAGs.
斯普伦多-赫普利现象是指在微生物和生物惰性物质周围在体内形成嗜酸性放射状结构，它可能类似放线菌性硫颗粒，并且已在生殖器外部位被认识到。在女性下生殖道，作者在有和没有宫内节育器的情况下都注意到了这些假放线菌性放射状颗粒（PAMRAGs）。为了阐明PAMRAGs 的性质和形态发生，通过一系列特殊染色研究了PAMRAGs 的光学显微镜形态特征。PAMRAGs 中不存在中央分支细丝或类白喉杆菌形态，这有助于将它们与真正的放线菌性硫颗粒区分开来。作者使用免疫过氧化物酶技术检测PAMRAGs 中免疫球蛋白、补体和纤维蛋白的存在。他们的研究表明，PAMRAGs 含有中性糖蛋白、脂质和钙，没有可证实的微生物、免疫球蛋白、补体或纤维蛋白。作者不支持其他人关于斯普伦多-赫普利放射体是源自宿主血清蛋白的免疫复合物的说法。他们推测，生殖道的PAMRAGs 源自宿主白细胞，这些白细胞是对通常存在的细菌、寄生虫或惰性异物作出反应而聚集的，这些异物引发了斯普伦多-赫普利现象和PAMRAGs 的形态发生。
