Thomas H C, Brown D, Labrooy J, Epstein O
J Clin Immunol. 1982 Jul;2(3 Suppl):57S-60S.
Review of the limited data currently available on the ratios of helper (OKT4+) to suppressor (OKT8+) T cells in autoimmune liver disease (primary biliary cirrhosis and chronic active lupoid hepatitis) and virally induced liver disease indicates that this OKT4+:OKT8+ ratio is elevated in autoimmune liver disease manifesting hyperglobulinemia. This ratio was decreased in patients with chronic hepatitis B virus infection during the HBe antigen-positive phase of viral replication but reverts to normal in the majority of patients in whom HBV replication has ceased (HBe antibody-positive) and these individuals exhibit normal liver histology. Patients with HBV infection who continue to show elevated ratios after the appearance of HBe antibody also continue to exhibit signs of active hepatitis. The implications of these findings for further research in the management of these disorders is discussed.
对自身免疫性肝病（原发性胆汁性肝硬化和慢性活动性狼疮样肝炎）以及病毒诱导性肝病中辅助性（OKT4 +）与抑制性（OKT8 +）T细胞比例的现有有限数据进行回顾表明，在表现为高球蛋白血症的自身免疫性肝病中，该OKT4 +:OKT8 +比例升高。在慢性乙型肝炎病毒感染患者处于病毒复制的HBe抗原阳性阶段时，该比例降低，但在大多数HBV复制已停止（HBe抗体阳性）且肝脏组织学正常的患者中，该比例恢复正常。在出现HBe抗体后仍显示比例升高的HBV感染患者也继续表现出活动性肝炎的迹象。讨论了这些发现对这些疾病管理方面进一步研究的意义。
