Hamann S R, Oeltgen P R, Shank W A, Blouin R A, Natarajan L
Ther Drug Monit. 1982;4(3):297-300. doi: 10.1097/00007691-198208000-00008.
The pharmacokinetics of gentamicin were examined in two functionally anephric patients undergoing peritoneal dialysis (PD). Peritoneal dialysis effectively decreased the gentamicin half-life (t1/2 beta) by 73 and 78% while increasing total body clearance [QB(ml/min/kg] of gentamicin 4.3- and 3.4-fold. The appreciable variability in gentamicin pharmacokinetics among renal failure patients being peritoneally dialyzed may necessitate dosage adjustments based on rapid and accurate measurement of serum gentamicin concentrations.
在两名接受腹膜透析（PD）的功能性无肾患者中研究了庆大霉素的药代动力学。腹膜透析有效地将庆大霉素的半衰期（t1/2β）降低了73%和78%，同时使庆大霉素的全身清除率[QB（毫升/分钟/千克）]提高了4.3倍和3.4倍。在接受腹膜透析的肾衰竭患者中，庆大霉素药代动力学存在明显差异，这可能需要根据血清庆大霉素浓度的快速准确测量来调整剂量。
