Schölzel E, Petropoulos P, Spycher M, Uhlschmid G
Thoraxchir Vask Chir. 1978 Jun;26(3):172-6. doi: 10.1055/s-0028-1096618.
In 12 mongrel dogs tracheal defects of different size were covered by bovine xenografts. The grafts were subjected to electronmicroscopic examination 2 to 19 months after implantation. Following the ingrowht of fibroblasts and capillaries a basal membrane is formed on the side of the previous graft lumen. After 4 to 5 months this membrane is covered from the tracheal margins by microvillous cells. After 8 months ciliated epithelia and goblet cells are developed by cell metaplasia. Although the graft becomes revitalized and integrated into the tracheal wall, the layer of ciliated epithelia is interrupted by less differentiated cells. The possible causes for this phenomenon are discussed. Thus bovine xenograft used for the repair of tracheal defects has the following advantages: total revitalization, no shrinkage, less prone to infection and formations of ciliated epithelia.
在12只杂种犬中，不同大小的气管缺损用牛异种移植物覆盖。植入后2至19个月对移植物进行电子显微镜检查。在成纤维细胞和毛细血管长入后，在前移植物管腔一侧形成基底膜。4至5个月后，该膜从气管边缘被微绒毛细胞覆盖。8个月后，通过细胞化生形成纤毛上皮和杯状细胞。尽管移植物恢复活力并整合到气管壁中，但纤毛上皮层被分化程度较低的细胞中断。讨论了这种现象的可能原因。因此，用于修复气管缺损的牛异种移植物具有以下优点：完全恢复活力、无收缩、不易感染且形成纤毛上皮。
