Satija N K, Seth T D, Tandon D S
Toxicology. 1978 May;10(1):13-6. doi: 10.1016/0300-483x(78)90050-1.
Acute plumbism include recurrent seizures, cerebral palsy and mental retardations. The impairment of the central nervous system (CNS) with increased lead absorption is of paramount concern which remains unsolved because of the lack of specific and sensitive neurochemical/biochemical indicators of the effect of lead on the CNS. In our experimental acute lead-zinc poisoning, significant increase in noradrenaline and slight decrease in dopamine have been found in the brains of rats, which suggest that there is change in neurotransmitter metabolism in lead poisoning.
急性铅中毒包括反复发作的癫痫、脑性瘫痪和智力发育迟缓。铅吸收增加导致的中枢神经系统（CNS）损害是最为关注的问题，由于缺乏铅对中枢神经系统影响的特异性和敏感性神经化学/生物化学指标，该问题仍未得到解决。在我们的实验性急性铅锌中毒中，发现大鼠大脑中去甲肾上腺素显著增加，多巴胺略有减少，这表明铅中毒时神经递质代谢发生了变化。
