发热：其历史、成因及功能。
Fever: its history, cause, and function.
作者信息
Atkins E
出版信息
Yale J Biol Med. 1982 May-Aug;55(3-4):283-9.
Abstract
Concepts of fever from Hippocrates to the present are briefly outlined and compared with current ideas of the pathogenesis of fever. Evidence is presented that endogenous pyrogen, the hormone that elevates body temperature, is identical with lymphocyte-activating factor, a monokine that stimulates lymphocyte proliferation and function.It now appears that inflammation and fever are closely interrelated phenomena that are modulated by a single hormone and that have been selected by evolution to protect the host against infection.
摘要
简要概述了从希波克拉底时代至今关于发热的概念，并与当前发热发病机制的观点进行了比较。有证据表明，内源性致热原这种使体温升高的激素，与淋巴细胞激活因子是同一物质，淋巴细胞激活因子是一种刺激淋巴细胞增殖和功能的单核因子。现在看来，炎症和发热是密切相关的现象，由单一激素调节，并且是通过进化选择来保护宿主免受感染的。
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