Abaru D E, McMahon J E
Tropenmed Parasitol. 1978 Jun;29(2):175-7.
Metrifonate, in doses of 10 mg/kg for 3 consecutive days, demonstrated partial microfilaricidal activity against Onchocerca volvulus in humans. Higher doses were not investigated because of the toxic reactions obtained and the absence of monitoring of the blood cholinesterase levels. Spaced doses of 10 mg/kg every 2 weeks or once monthly up to 3 doses showed neither micro- nor macrofilaricidal activity against Wuchereria bancrofti.
敌百虫以10毫克/千克的剂量连续给药3天，对人体盘尾丝虫显示出部分杀微丝蚴活性。由于出现毒性反应且未监测血液胆碱酯酶水平，未对更高剂量进行研究。每2周或每月一次间隔给予10毫克/千克剂量，最多3剂，对班氏吴策线虫既无杀微丝蚴活性也无杀成虫活性。
