Breslow A, Cascinelli N, van der Esch E P, Morabito A
Tumori. 1978 Jun 30;64(3):273-84. doi: 10.1177/030089167806400305.
The prognostic significance of 2 histological parameters, level of invasion and maximum thickness is evaluated in 248 cases of malignant melanoma of the limbs staged T1-3NoMo which were collected for Trial No. 1 of the W.H.O. Collaborating Centres for the Evaluation of Methods of Diagnosis and Treatment of Melanoma between September 1967 and December 1974. There is a linear relation of tumor thickness to mortality with a high statistical significance (P = 0.0002). Mortality also increases with progression of the level of invasion. The incidence of occult metastases to the regional lymph nodes increases with increasing thickness or level of invasion. Moreover the age and sex corrected survival curves are also dependent on both parameters. The comparison of the 2 methods revealed that maximal tumor thickness is a more powerful measure of prognosis than is the determination of the level of invasion.
对1967年9月至1974年12月期间为世界卫生组织黑色素瘤诊断与治疗方法评估合作中心试验1收集的248例T1 - 3NoMo期肢体恶性黑色素瘤患者，评估了两个组织学参数（浸润深度和最大厚度）的预后意义。肿瘤厚度与死亡率呈线性关系，具有高度统计学意义（P = 0.0002）。死亡率也随着浸润深度的进展而增加。区域淋巴结隐匿性转移的发生率随着厚度或浸润深度的增加而增加。此外，校正年龄和性别的生存曲线也取决于这两个参数。两种方法的比较显示，最大肿瘤厚度比浸润深度的测定更能有力地预测预后。
