Int J Cancer. 1980 Dec 15;26(6):733-9. doi: 10.1002/ijc.2910260606.
Prognosis of stage I melanoma of the skin was evaluated in 747 previously untreated patients observed by the WHO Collaborating Centres for Evaluation of Methods of Diagnosis and Treatment of Melanoma from September 1967 to September 1975. The mean followup period of these patients was 8.9 years. Sex, maximum diameter of melanoma, elevation on skin surface, histologic type, levels of invasion and maximum tumor thickness were found to be significantly related to survival when considered one by one. However, multifactorial analysis showed that sex and maximum thickness only had a significant impact on survival of stage I melanoma patients. The effect of sex was not evident in patients with maximum tumor thickness not exceeding 2 mm (81% 5-year survival for males and 87% for females and a p value greater than 0.05), while females did significantly better (p less than 10(-4) when maximum thickness of primary was over 2 mm.
1967年9月至1975年9月期间，世界卫生组织黑色素瘤诊断与治疗方法评估合作中心对747例未经治疗的I期皮肤黑色素瘤患者的预后进行了评估。这些患者的平均随访期为8.9年。逐一分析时发现，性别、黑色素瘤最大直径、皮肤表面隆起程度、组织学类型、浸润深度和肿瘤最大厚度与生存率显著相关。然而，多因素分析表明，只有性别和最大厚度对I期黑色素瘤患者的生存有显著影响。在肿瘤最大厚度不超过2mm的患者中，性别差异不明显（男性5年生存率为81%，女性为87%，p值大于0.05），而当原发肿瘤最大厚度超过2mm时，女性的生存率显著更高（p小于10^(-4)）。
