Weaver E A, Tsuda H, Goldblum R M, Goldman A S, Davis C P
Infect Immun. 1982 Dec;38(3):1073-7. doi: 10.1128/iai.38.3.1073-1077.1982.
Macrophages and neutrophils that contain mainly secretory immunoglobulin A (IgA) comprise the majority of cells in human colostrum. These cell populations were separated and analyzed for their ability to release total IgA and secretory IgA when stimulated to phagocytose. Colostral macrophages phagocytosed opsonized bacteria and nonopsonized latex particles; at the same time, IgA was released. Neutrophils poorly phagocytosed opsonized bacteria but actively phagocytosed latex particles. In contrast to the macrophages, the neutrophils did not release IgA, even after active phagocytosis of latex. Consequently, colostral macrophages are the main source of IgA released from colostral leukocytes when these cells are exposed to organisms or particles that are phagocytosed. A function for colostral neutrophils which sequester IgA is proposed.
主要含有分泌型免疫球蛋白A（IgA）的巨噬细胞和中性粒细胞构成了人初乳中细胞的大部分。分离这些细胞群体，并分析它们在被刺激吞噬时释放总IgA和分泌型IgA的能力。初乳巨噬细胞吞噬调理过的细菌和未调理的乳胶颗粒；与此同时，IgA被释放。中性粒细胞对调理过的细菌吞噬能力较差，但能积极吞噬乳胶颗粒。与巨噬细胞不同，即使在对乳胶进行活跃吞噬后，中性粒细胞也不释放IgA。因此，当初乳白细胞暴露于被吞噬的生物体或颗粒时，初乳巨噬细胞是初乳白细胞释放IgA的主要来源。有人提出了初乳中性粒细胞隔离IgA的功能。
