Scadding J W, Wall P D, Parry Wynn C B, Brooks D M
Royal National Orthopaedic Hospital, Great Portland Street, London W1 and Cerebral Functions Research Group, Department of Anatomy, University College London, Cower St., London WC1 Great Britain.
Pain. 1982 Nov;14(3):283-292. doi: 10.1016/0304-3959(82)90135-X.
In view of several case reports of relief of various neuralgias by propranolo, a double-blind cross-over trial using this drug was conducted in 10 patients with severe persistent pain and paraesthesiae following upper limb peripheral nerve injuries. The patients received up to 240 mg of propranolol per day. Only one patient reported pain relief, but this patient withdrew from the trial. An open trial of propranolol was conducted in 6 other patients with a variety of peripheral nerve lesions. Of these, neuroma tenderness was transiently reduced in one patient and the hyperaesthesia of a painful scar was relieved in another. Routine use of propranolol in such patients cannot be recommended.
鉴于有几例关于普萘洛尔缓解各种神经痛的病例报告，对10例上肢周围神经损伤后患有严重持续性疼痛和感觉异常的患者进行了使用该药物的双盲交叉试验。患者每天服用高达240毫克的普萘洛尔。只有1例患者报告疼痛缓解，但该患者退出了试验。对另外6例患有各种周围神经病变的患者进行了普萘洛尔的开放试验。其中，1例患者的神经瘤压痛暂时减轻，另1例患者疼痛瘢痕的感觉过敏得到缓解。不建议在此类患者中常规使用普萘洛尔。
