Powers J M, Sullivan L, Rosenthal C J
Acta Neuropathol. 1982;58(4):275-8. doi: 10.1007/BF00688609.
Immunoreactivity for AA protein was rarely detected in briefly fixed amyloid of senile plaques and dyshoric angiopathy, but was not observed in Congophilic angiopathy. Plaque and dyshoric amyloid exhibited variable sensitivity to permanganate oxidation; Congophilic angiopathy was resistant to oxidation. In contrast to systemic amyloid composed of AA protein, the rare immunoreactivity of senile cerebral amyloid was lost with prolonged fixation. This study demonstrates that the fibrillar protein of senile cerebral amyloid differs from that of systemic amyloid of AA type.
在老年斑和发育异常性血管病的短时间固定淀粉样物中很少检测到AA蛋白的免疫反应性，但在嗜刚果红性血管病中未观察到。斑块和发育异常性淀粉样物对高锰酸钾氧化表现出不同的敏感性；嗜刚果红性血管病对氧化有抗性。与由AA蛋白组成的全身性淀粉样物不同，老年脑淀粉样物的罕见免疫反应性会随着固定时间延长而消失。本研究表明，老年脑淀粉样物的纤维状蛋白与AA型全身性淀粉样物的纤维状蛋白不同。
