Hauguel S, Gilbert M, Cedard L
Biol Neonate. 1982;42(5-6):257-64. doi: 10.1159/000241607.
The metabolic action of salbutamol in fetuses was studied after acute (day 21 of pregnancy) and chronic (5 daily infusions from day 16 to day 20 of pregnancy) treatment of pregnant rats. A single injection of salbutamol on day 21 of gestation induced an increase in plasma insulin levels prior to the rise of blood glucose concentration. After the chronic treatment, fetuses from treated mothers showed a decrease in insulin-secreting ability in response to a maternal glucose injection. However, no modifications in fetal liver and placental glycogen contents or in birth weight could be demonstrated. These results suggest that a chronic treatment of pregnant rats with salbutamol could affect the fetal pancreatic responsiveness to glucose.
在对妊娠大鼠进行急性（妊娠第21天）和慢性（从妊娠第16天至第20天每天输注一次，共5次）治疗后，研究了沙丁胺醇在胎儿体内的代谢作用。在妊娠第21天单次注射沙丁胺醇后，血糖浓度升高之前血浆胰岛素水平就有所升高。慢性治疗后，经治疗的母亲所生的胎儿对母体注射葡萄糖的反应显示胰岛素分泌能力下降。然而，未发现胎儿肝脏和胎盘糖原含量或出生体重有变化。这些结果表明，用沙丁胺醇对妊娠大鼠进行慢性治疗可能会影响胎儿胰腺对葡萄糖的反应性。
