Evelegh M J, Clark D A, McCandless E L
Immunol Lett. 1982 Nov;5(5):247-52. doi: 10.1016/0165-2478(82)90107-9.
We found that 1 mg of carrageenan (CGN) could enhance the primary antibody response of BALB/c spleen cells to sheep erythrocytes (SRBC). This enhancement was dependent on the strain of mouse injected as well as the type of CGN administered. In vitro experiments with spleen cells from mice treated with CGN in vivo showed that these cells release low molecular weight factor(s) which enhanced the in vitro antibody response to SRBC. Thy 1+ cells were clearly involved in the production of this factor since depletion of these cells eliminated the helper effect of CGN-treated spleen cells. Our results suggest one possible mechanism by which CGN can modulate the immune response.
我们发现，1毫克角叉菜胶（CGN）可增强BALB/c脾细胞对绵羊红细胞（SRBC）的初次抗体反应。这种增强作用取决于所注射小鼠的品系以及所给予的CGN类型。对体内用CGN处理过的小鼠的脾细胞进行的体外实验表明，这些细胞释放出低分子量因子，该因子增强了体外对SRBC的抗体反应。Thy 1+细胞显然参与了该因子的产生，因为去除这些细胞消除了CGN处理的脾细胞的辅助作用。我们的结果提示了CGN调节免疫反应的一种可能机制。
