Gorman N T, Lachmann P J
Clin Exp Immunol. 1982 Dec;50(3):507-14.
In the presence of optimal concentrations of both anti-viral IgG and complement, cells persistently infected with either measles virus (DS6-PI) or canine distemper virus (CDV-PI) could be lysed. In contrast, in the presence of adequate concentrations of anti-viral IgG but no complement the viral antigens expressed on the cell surface of DS6-PI and CDV-PI cells were lost, i.e. the cells were modulated. It was however possible to show that with critical concentrations of anti-viral IgG but with only moderately depressed levels of complement, modulation of the cells rather than lysis could occur. The implication that this may have in the generation of persistent viral infections in vivo is discussed.
在同时存在最佳浓度的抗病毒IgG和补体的情况下，持续感染麻疹病毒（DS6-PI）或犬瘟热病毒（CDV-PI）的细胞可能会被裂解。相比之下，在存在足够浓度的抗病毒IgG但没有补体的情况下，DS6-PI和CDV-PI细胞表面表达的病毒抗原会丢失，即细胞被调节。然而，可以证明，在抗病毒IgG浓度临界但补体水平仅适度降低的情况下，可能会发生细胞调节而非裂解。文中讨论了这一现象在体内持续性病毒感染产生过程中可能具有的意义。
