聚合物前列腺素PGBx对遗传性糖尿病小鼠降血糖作用机制的初步研究。胰岛素反应曲线。
A preliminary study of the mechanism of the hypoglycemic effect of polymeric prostaglandin PGBx in hereditary diabetic mice. Insulin response curves.
作者信息
Cope F W
出版信息
Physiol Chem Phys. 1982;14(5):420-2.
PMID:6764668
Abstract
Polymeric prostaglandin PGBx normalizes the high blood sugar seen in hereditary diabetic mice. PGBx does not enhance the sensitivity of these mice to the hypoglycemic effect of insulin. It is therefore proposed that the hypoglycemic effect of PGBx may be an indirect consequence of induction of increased consumption by genetically defective mitochondria of two and three carbon fragments produced at the bottom of the glycolysis chain.
摘要
聚合前列腺素PGBx可使遗传性糖尿病小鼠的高血糖恢复正常。PGBx不会增强这些小鼠对胰岛素降血糖作用的敏感性。因此有人提出，PGBx的降血糖作用可能是由于遗传缺陷的线粒体增加了对糖酵解链末端产生的二碳和三碳片段的消耗而间接产生的结果。
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