Dose-dependent reduction of hereditary obesity in the non-diabetic mouse by polymeric prostaglandin PGBx.

Mice genetically obese but not diabetic show large reductions of excessive body weight and excessive food intake when treated with polymeric prostaglandin PGBx. Larger doses of PGBx produce greater reduction of both body weight and food consumption, in agreement with dose-dependent effects of PGBx observed previously in the genetically diabetic mouse. Only minor effects of PGBx on blood glucose were observed. This suggests that PGBx effects on obesity and appetite are not mediated through a blood glucose mechanism.