Paton J C, Lawrence A J, Manson J I
J Clin Microbiol. 1982 Jan;15(1):1-4. doi: 10.1128/jcm.15.1.1-4.1982.
A 4-month-old boy presented with symptoms and signs characteristic of infant botulism. Examination of feces revealed Clostridium botulinum type B and type B toxin. The numbers of C. botulinum and the amount of toxin in feces were measured throughout the 4-week period in hospital. The maximum numbers and amounts were detected in a fecal specimen collected 16 days after admission: this contained 8.4 X 10(6) C. botulinum type B colony-forming units and 61,440 mouse 100% lethal doses of type B toxin per g (wet weight) of feces. This latter figure is the highest fecal toxin titer reported yet for a case of infant botulism. By day 16, however, substantial improvement in the patient's clinical condition had occurred. This suggests that initiation of recovery from infant botulism is not necessarily preceded by a reduction in the numbers of C. botulinum organisms and the quantity of toxin in the gut.
一名4个月大的男婴出现了婴儿肉毒中毒的症状和体征。粪便检查发现了B型肉毒梭菌和B型毒素。在住院的4周时间里，对粪便中的肉毒梭菌数量和毒素量进行了测量。入院16天后采集的一份粪便标本中检测到了最大数量和含量：每克（湿重）粪便中含有8.4×10(6)个B型肉毒梭菌菌落形成单位和61440个小鼠100%致死剂量的B型毒素。后一个数字是迄今报道的婴儿肉毒中毒病例中粪便毒素滴度最高的。然而，到第16天，患者的临床状况已出现显著改善。这表明婴儿肉毒中毒开始恢复并不一定先出现肠道内肉毒梭菌数量和毒素量的减少。
