Leathwood P D, Chauffard F
J Psychiatr Res. 1982;17(2):115-22. doi: 10.1016/0022-3956(82)90013-9.
In quantifying the effects of mild sedatives both physiological and subjective aspects of sleep must be taken into account. A questionnaire analysis on a mild sedative (400 mg of an aqueous extract of Valeriana officinalis L.) showed that by subjective criteria it is sedative (i.e. it significantly decreased perceived sleep latencies and night awakenings, and improved sleep quality). In an EEG study on the same preparation the pattern of results tended to confirm the subjective evaluation (i.e. shorter mean sleep latency, increased mean latency to first awakening) but the changes did not reach statistical significance. The discussion critically examines some of the approaches used to test putative mild sedatives and suggests a rational approach to analysing their effects.
在量化轻度镇静剂的效果时，必须兼顾睡眠的生理和主观方面。对一种轻度镇静剂（400毫克缬草水提取物）进行的问卷调查分析表明，按照主观标准，它具有镇静作用（即显著缩短了入睡时间和夜间觉醒时间，并改善了睡眠质量）。在对同一制剂进行的脑电图研究中，结果模式倾向于证实主观评价（即平均睡眠潜伏期缩短，首次觉醒的平均潜伏期延长），但这些变化未达到统计学显著性。讨论严格审查了一些用于测试假定的轻度镇静剂的方法，并提出了一种分析其效果的合理方法。
