Leathwood P D, Chauffard F, Heck E, Munoz-Box R
Pharmacol Biochem Behav. 1982 Jul;17(1):65-71. doi: 10.1016/0091-3057(82)90264-7.
The effect of an aqueous extract of valerian (Valeriana officinalis L.) root on subjectively rated sleep measures was studied on 128 people. Each person received 9 samples to test (3 containing placebo, 3 containing 400 mg valerian extract and 3 containing a proprietary over-the-counter valerian preparation). The samples, identified only by a code number, and presented in random order, were taken on non-consecutive nights. Valerian produced a significant decrease in subjectively evaluated sleep latency scores and a significant improvement in sleep quality: the latter was most notable among people who considered themselves poor or irregular sleepers, smokers, and people who thought they normally had long sleep latencies. Night awakenings, dream recall and somnolence the next morning were relatively unaffected by valerian. With the proprietary valerian-containing preparation, the only change was a significant increase in reports of feeling more sleepy than normal the next morning. Thus the questionnaire, simple to use and non-invasive, provides a sensitive means for detecting the effects of mild sedatives on different aspects of sleep in man. It also allows identification within the test population of the subgroups most affected.
对128人研究了缬草根水提取物对主观评定睡眠指标的影响。每人接受9个样本进行测试（3个含安慰剂，3个含400毫克缬草提取物，3个含一种非处方缬草制剂）。样本仅用编号标识，随机排列，在非连续的夜晚服用。缬草使主观评估的入睡潜伏期得分显著降低，睡眠质量显著改善：在自认为睡眠质量差或不规律的人、吸烟者以及认为自己通常入睡潜伏期长的人群中，后者最为明显。夜间觉醒、梦境回忆和次日嗜睡相对不受缬草影响。使用含缬草的非处方制剂时，唯一的变化是次日感觉比平时更困倦的报告显著增加。因此，该问卷使用简单且无创，是检测轻度镇静剂对人类睡眠不同方面影响的灵敏方法。它还能在测试人群中识别出受影响最大的亚组。
