Hanaoka M
Acta Pathol Jpn. 1982;32 Suppl 1:171-85.
The clustering incidence of adult T cell leukemia (ATL) is found in adult populations who were born in southwest Japan and showed impairment of cell-mediated immunity; all patients with ATL contain antibody for specific ATL associated antigen in their sera. This ATLA positive T cell leukemia is morphologically characterized by leukemic cells in various sizes showing unique nuclear polymorphism. The neoplastic cells bear common immunocytologic markers with inducer T cell subset among the peripheral T2 cell group and functionally show the suppressor inducer activity. Histologic features of lymph nodes were classified to diffuse lymphoma, pleomorphic type in many cases of ATL. The prognosis of patients with ATL is the worst among lymphoid malignancies and almost all patients died within a year accompanied by pulmonary lesions or other infectious inflammatory lesions.
成人T细胞白血病（ATL）的聚集性发病见于出生于日本西南部且细胞介导免疫功能受损的成年人群；所有ATL患者血清中均含有针对特定ATL相关抗原的抗体。这种ATLA阳性T细胞白血病在形态学上的特征是白血病细胞大小各异，呈现独特的核多形性。肿瘤细胞在外周T2细胞群中与诱导性T细胞亚群具有共同的免疫细胞标记，并且在功能上表现出抑制诱导活性。在许多ATL病例中，淋巴结的组织学特征分类为弥漫性淋巴瘤，多形型。ATL患者的预后在淋巴恶性肿瘤中最差，几乎所有患者在一年内死亡，伴有肺部病变或其他感染性炎症病变。
