Shibata A, Aoyagi Y, Aoki S
Jpn J Clin Oncol. 1983 Dec;13(4):657-66.
Eight patients with adult T-cell leukemia (ATL) were observed at Niigata University Hospital during the last seven years. They had typical hematological findings of ATL. All patients tested possessed both natural antibody against ATL-associated antigens (ATLA) in the serum and ATLA in peripheral mononuclear cells. These findings agree with the results of virological analysis in patients with ATL in other areas of Japan and human T-cell leukemia (HTL) in the U.S.A. Six out of the eight patients were native residents of Sado Island in Niigata Prefecture. They showed somewhat different clinical features from patients in other endemic areas and a variety of skin lesions. It was noticeable that the skin lesion regressed spontaneously in two patients. In view of the fact that the total population of this island is about 80,000, the incidence of ATL is thought to be high. Immunological studies were performed in our patients and the immunological background of ATL is discussed.
在过去七年中，新潟大学医院观察了8例成人T细胞白血病（ATL）患者。他们具有典型的ATL血液学表现。所有检测的患者血清中均含有针对ATL相关抗原（ATLA）的天然抗体，外周血单个核细胞中也含有ATLA。这些发现与日本其他地区ATL患者以及美国人类T细胞白血病（HTL）患者的病毒学分析结果一致。8例患者中有6例是新潟县佐渡岛的本地居民。他们表现出与其他流行地区患者略有不同的临床特征和多种皮肤病变。值得注意的是，两名患者的皮肤病变自发消退。鉴于该岛总人口约为8万，ATL的发病率被认为较高。我们对患者进行了免疫学研究，并讨论了ATL的免疫背景。
