Jahr H, Marx S, Besch W, Ratzmann K P
Acta Biol Med Ger. 1982;41(12):1099-1103.
Isolated pancreatic islets from 7-10 days old Wistar rats were incubated in freshly prepared human serum. The cytotoxic insulin leakage from the islets was correlated with the presence in the sera of islet cell surface antibodies (ICSA) determined by indirect immunofluorescence. Such cytotoxic ICSA were found to be common in Type-I diabetics as well as in nondiabetic subjects who had contact with laboratory rats.
将7 - 10日龄Wistar大鼠的分离胰岛在新鲜制备的人血清中孵育。胰岛细胞毒性胰岛素泄漏与通过间接免疫荧光法测定的血清中胰岛细胞表面抗体（ICSA）的存在相关。发现这种细胞毒性ICSA在I型糖尿病患者以及接触过实验大鼠的非糖尿病受试者中很常见。
