Penner J L, Preston M A, Hennessy J N, Barton L J, Goodbody M M
Antimicrob Agents Chemother. 1982 Aug;22(2):218-21. doi: 10.1128/AAC.22.2.218.
Six cephalosporins and three aminoglycosides were examined for activity against 1,693 isolates belonging to six species of Proteeae. The most notable species-specific differences included the marked susceptibility of Providencia alcalifaciens and Proteus mirabilis to cephalothin, the resistance of Proteus vulgaris to cefamandole, and the resistance of Providencia stuartii to gentamicin and tobramycin. The third-generation cephalosporins cefotaxime and moxalactam were substantially more inhibitory than were cefoperazone, cefamandole, and cefoxitin. P. stuartii, generally the most resistant species, was, however, markedly susceptible to moxalactam and cefotaxime.
检测了六种头孢菌素和三种氨基糖苷类药物对属于变形杆菌属六个菌种的1693株分离菌的活性。最显著的种属特异性差异包括产碱普罗威登斯菌和奇异变形杆菌对头孢噻吩的显著敏感性、普通变形杆菌对头孢孟多的耐药性以及斯氏普罗威登斯菌对庆大霉素和妥布霉素的耐药性。第三代头孢菌素头孢噻肟和拉氧头孢的抑制作用明显强于头孢哌酮、头孢孟多和头孢西丁。然而,通常最耐药的斯氏普罗威登斯菌对拉氧头孢和头孢噻肟却明显敏感。