Louis-Sylvestre J, Le Magnen J
Neurosci Biobehav Rev. 1980;4 Suppl 1:13-5. doi: 10.1016/0149-7634(80)90041-x.
It has been suggested for a long time that the metabolic stimulation to eat or the hunger arousal of eating, originated from a fall in the blood glucose level induced by the periodic failure of hepatic glucose production to match the peripheral glucose uptake. However, this suggestion has not been substantiated directly by the results of periodic blood glucose evaluations performed during intermeal intervals in free-fed rats. In this experiment, a technique involving a continuous blood glucose determination over several hours was used in free-feeding, undisturbed rats. It was shown that all nocturnal and diurnal meals were preceded by a 6 to 8% fall of blood level, starting 5 to 6 min prior to meal onset. The overall consequences of these findings are discussed.
长期以来，人们一直认为进食的代谢刺激或进食时的饥饿感源于肝脏葡萄糖生成周期性无法与外周葡萄糖摄取相匹配导致的血糖水平下降。然而，在自由进食的大鼠餐间间隔期进行的周期性血糖评估结果并未直接证实这一观点。在本实验中，对自由进食、未受干扰的大鼠使用了一种在数小时内连续测定血糖的技术。结果显示，所有夜间和白天的进食之前，血糖水平都会在进食开始前5至6分钟开始下降6%至8%。本文讨论了这些发现的总体影响。
