Smedegård G, Revenäs B, Saldeen T
Int Arch Allergy Appl Immunol. 1980;61(2):117-24. doi: 10.1159/000232424.
Haematological and histological studies were made following challenge in 8 monkeys (Macaca irus) sensitized with ovalbumin. Haemagglutinating, but no reaginic antibodies to ovalbumin were demonstrated before challenge. Both platelet and leucocyte counts decreased markedly (-80 and -89%, respectively) within 5 min after challenge. No evidence of haemoconcentration was found. Plasma fibrinogen decreased (-74%), indicating activation of the coagulation system. Histological examination revealed platelets, leucocytes, fibrin and a large number of hyaline globuli ('globular microemboli') in pulmonary capillaries and small arterioles. From their staining properties the globuli were considered to consist mainly of fibrin. Some globuli were also found in the liver and kidneys, but were rarely seen in other organs. It is concluded that the anaphylactic reaction in this experimental model can be classified as aggregate anaphylaxis, and it is suggested that platelet mediators play an important role in the early pulmonary vascular and respiratory response.
对8只经卵清蛋白致敏的猕猴（食蟹猴）进行激发试验后，开展了血液学和组织学研究。激发试验前检测到了针对卵清蛋白的血凝抗体，但未检测到反应素抗体。激发试验后5分钟内，血小板计数和白细胞计数均显著下降（分别下降80%和89%）。未发现血液浓缩迹象。血浆纤维蛋白原减少（-74%），表明凝血系统被激活。组织学检查显示，肺毛细血管和小动脉中有血小板、白细胞、纤维蛋白和大量透明球状物（“球状微栓子”）。根据其染色特性，这些球状物被认为主要由纤维蛋白组成。在肝脏和肾脏中也发现了一些球状物，但在其他器官中很少见。结论是，该实验模型中的过敏反应可归类为聚集性过敏反应，提示血小板介质在早期肺血管和呼吸反应中起重要作用。
