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蛛猴疱疹病毒和松鼠猴疱疹病毒与灵长类淋巴细胞的相互作用。I. 淋巴样细胞对病毒的选择性吸附。

Interaction of Herpesvirus ateles and Hepesvirus saimiri with primate lymphocytes. I. Selective adsorption of virus by lymphoid cells.

作者信息

Johnson D R, Klein G, Falk L

出版信息

Intervirology. 1980;13(1):21-7. doi: 10.1159/000149102.

DOI:10.1159/000149102
PMID:6766914
Abstract

A semiquantitative infectious bioassay, described by Sairenji and Hinuma for the measurement of Epstein-Barr virus (EBV) receptors, was adapted to study the adsorption of the lymphotropic New World herpesvirus ateles (HVA) to established lymphoid lines and lymphocytes of human versus marmoset origin. All marmoset T-cell lines [HVA- or HVS (herpesvirus saimiri)-carrying] had a high adsorbing capacity. EBV-carrying marmoset or human B-cell lines, one EBV-negative human B-lymphoma line, and one human myeloid leukemia-derived line failed to adsorb detectable virus. Two human T-cell derived cell lines of acute lymphatic leukemia origin showed moderate but significant adsorption, and the same was true for unfractionated marmoset lymphocytes. Human peripheral blood did not adsorb, before or after fractionation, whereas normal human thymocytes showed moderate but significant adsorption. It is concluded that HVA receptors are present on human T cells, probably belonging to certain subclasses.

摘要

Sairenji和Hinuma描述的一种用于测量爱泼斯坦-巴尔病毒(EBV)受体的半定量感染性生物测定法,被用于研究嗜淋巴细胞的新大陆疱疹病毒阿特勒斯病毒(HVA)对已建立的人源和狨猴源淋巴样细胞系及淋巴细胞的吸附作用。所有狨猴T细胞系(携带HVA或猴疱疹病毒HVS)都有很高的吸附能力。携带EBV的狨猴或人B细胞系、一个EBV阴性的人B淋巴瘤细胞系以及一个人髓系白血病衍生细胞系均未能吸附可检测到的病毒。两个源自急性淋巴细胞白血病的人T细胞系表现出中等程度但显著的吸附作用,未分离的狨猴淋巴细胞也是如此。人外周血在分离前后均未吸附,而正常人胸腺细胞表现出中等程度但显著的吸附作用。结论是HVA受体存在于人T细胞上,可能属于某些亚类。

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