Korsnes L, Gedde-Dahl T
Ann Hum Genet. 1980 Jan;43(3):199-212. doi: 10.1111/j.1469-1809.1980.tb01554.x.
A study of 948 Norwegians including 118 matings with 429 children provided evidence that the Pg I group of pepsinogens must be coded for by more than one gene locus. At the Pg5 locus the alleles Pg5N, Pg5F and Pg5S with frequencies 0.644, 0.059 and 0.004, each code for a single electrophoretic isozyme band responsible for Pg phenotypes Pg 5, intense Pg (4) and Pg 5S, and a null-allele Pg5o with frequency 0.293. The Pg 2, Pg 3 and weak Pg 4 bands are not coded for by alleles at the Pg5 locus and differ from the Pg5 gene products in the oligopeptides split off by pepsinogen-pepsin conversion. The Pg5 alleles differ from each other in the pepsin-coding part of the gene. Intensity variations of Pg 5 have no simple genetic explanation.
一项对948名挪威人的研究（其中包括118对配偶及429名子女）提供了证据，表明胃蛋白酶原的Pg I组必定由不止一个基因座编码。在Pg5基因座上，等位基因Pg5N、Pg5F和Pg5S的频率分别为0.644、0.059和0.004，它们各自编码一条单一的电泳同工酶带，分别对应Pg表型Pg 5、强Pg(4)和Pg 5S，还有一个频率为0.293的无效等位基因Pg5o。Pg 2、Pg 3和弱Pg 4带并非由Pg5基因座上的等位基因编码，并且在胃蛋白酶原-胃蛋白酶转化过程中裂解出的寡肽方面与Pg5基因产物不同。Pg5等位基因在基因的胃蛋白酶编码部分彼此不同。Pg 5的强度变化没有简单的遗传学解释。
