Shaywitz B A, Yager R D, Klopper J H
Science. 1976 Jan 23;191(4224):305-8. doi: 10.1126/science.942800.
Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected children. This suggests a functional deficiency of brain dopamine in the pathogenesis of minimal brain dysfunction.
给新生大鼠注射6-羟基多巴胺会导致脑内多巴胺迅速且大量减少。在12至22日龄期间，接受治疗的动物的总活动量显著高于对照组，但随后下降，这种活动模式与受影响儿童中观察到的相似。这表明脑多巴胺功能缺陷在轻微脑功能障碍的发病机制中起作用。
