早产和晚产对大鼠胆红素、吗啡和睾酮的UDP-葡糖醛酸基转移酶活性发育的影响。
The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat.
作者信息
Campbell M T, Wishart G J
出版信息
Biochem J. 1980 Feb 15;186(2):617-9. doi: 10.1042/bj1860617.
Abstract
In the rat, UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone increase markedly after normal or premature birth. This rapid development is superimposed upon a much slower maturation of activity which occurs in utero during the last 2 days of normal gestation and gestation when birth is delayed. Development of all three activities is similar under these different conditions, suggesting a common developmenpal regulatory mechanism.
摘要
在大鼠中，正常出生或早产之后，针对胆红素、吗啡和睾酮的UDP - 葡萄糖醛酸基转移酶活性会显著增加。这种快速发展叠加在子宫内正常妊娠最后两天以及出生延迟时妊娠期间发生的慢得多的活性成熟过程之上。在这些不同条件下，这三种活性的发展相似，表明存在共同的发育调节机制。
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The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat.早产和晚产对大鼠胆红素、吗啡和睾酮的UDP-葡糖醛酸基转移酶活性发育的影响。
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The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver.人肝脏中胆红素UDP-葡糖醛酸基转移酶活性的产前和产后发育以及早产对该活性的影响。
Biochem J. 1981 Apr 15;196(1):257-60. doi: 10.1042/bj1960257.
本文引用的文献
1
Precocious development of UDP-glucuronyltransferase activity in chick-embryo liver after administration of adrenocorticotropic hormone and of certain 11beta-hydroxy corticosteroids.促肾上腺皮质激素及某些11β-羟基皮质类固醇给药后鸡胚肝脏中UDP-葡萄糖醛酸基转移酶活性的早熟发育。
Biochem J. 1976 Aug 15;158(2):419-26. doi: 10.1042/bj1580419.
2
3
Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates.UDP-葡萄糖醛酸基转移酶的功能异质性，表现为其发育差异及糖皮质激素诱导性。证明该酶对十二种底物的活性存在两组差异。
Biochem J. 1978 Aug 15;174(2):485-9. doi: 10.1042/bj1740485.
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