狮尾猕猴实验性钩端螺旋体病的代谢后遗症
Metabolic sequelae of experimental leptospirosis in grivet monkeys.
作者信息
Hambleton P, Baskerville A, Marshall R B, Harris-Smith P W, Adams G D
出版信息
Br J Exp Pathol. 1980 Feb;61(1):16-21.
Abstract
Leptospira interrogans serovars balcanica and tarassovi both induced mild subclinical infections in grivet monkeys. The activities in serum of lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, aspartate aminotransferase, alanine aminotransferase and creatine phosphokinase and the level of alpha 1-antichymotrypsin increased in a few days after infection. Concomitant decreases in serum iron levels were observed in some cases. These changes occurred in the absence of any observable clinical signs though there were histopathological lesions in some organs. No haematological changes or alterations in other sreum components were detected.
摘要
问号钩端螺旋体巴尔干尼亚血清型和塔拉索夫血清型均可在狮尾猕猴中引发轻度亚临床感染。感染后数天，血清中乳酸脱氢酶、α-羟丁酸脱氢酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶和肌酸磷酸激酶的活性以及α1-抗糜蛋白酶水平升高。部分病例中观察到血清铁水平随之下降。尽管部分器官存在组织病理学损伤，但这些变化发生时并无任何可观察到的临床体征。未检测到血液学变化或其他血清成分的改变。
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